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Cassie Mitchell, PhD, RDN

Cassie Mitchell, PhD, RDN

Assistant Professor, Department of Pediatrics; Director of Nutrition Research for the Harold Hamm Diabetes Center

cassie-mitchell@ou.edu

Dr. Cassie M. Mitchell is an Assistant Professor of Pediatrics within the Section of Pediatric Diabetes and Endocrinology at the University of Oklahoma Children's Hospital and TSET Health Promotion Research Center. She is the Director of Nutrition Research for the Harold Hamm Diabetes Center, a Registered Dietitian Nutritionist (RDN), and a member of the OU Health Campus' Stephenson Cancer and Harold Hamm Diabetes Centers. She is also an affiliate member of the Native American Center for Cancer Health Excellence and the Center for Indigenous Resilience, Culture, and Maternal Health Equity. 

Dr. Mitchell has more than a decade of training in nutrition, exercise physiology, and health promotion. She completed two postdoctoral research fellowships and obtained three grants at local and national levels (HHDC, ADA, and NIH) during her training. Her research program focuses on the development and translation of clinical nutrition research to inform community Food Is Medicine interventions. In particular, Dr. Mitchell is  interested in nutrition and Food Is Medicine to support the health of women and Indigenous community members of Oklahoma across the lifespan.

On a final note, Dr. Mitchell is extremely passionate about mentoring under-represented minorities, as she herself is a proud member of the Citizen Potawatomi Nation and a first-generation college graduate. 

Education:

Education:

  • 2018, PhD in Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, VA
  • 2014, MS in Nutritional Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK
  • 2012, BS in Health and Exercise Science, Minor in Spanish, University of Oklahoma, Norman, OK

Postgraduate Education:

  • 2019, RDN training at Phoenix Indian Medical Center, Indian Health Services, Phoenix, AZ
  • 2022, Postdoctoral Research Fellow, Obesity and Diabetes Clinical Research Center, NIDDK-NIH, Phoenix, AZ
  • 2024, Senior Postdoctoral Research Fellow, Harold Hamm Diabetes Center, Oklahoma City, OK

Funding:

1R01HD117197 (MPI: Isganaitis, Rudolph, Fields | Role: Co-Investigator) 
NIH/NIDDK 
04/01/2025 - 03/31/2030 
Maternal exercise during lactation to ignite infant metabolism.  
Total costs: $3,289,545 

American Diabetes Center (PI: Mitchell) 
11/15/2023-11/15/2025 
Dissecting the role of maternal nutrition on liver health: Implications for mother and baby.  
Total costs: $228,684 

L40DK137367-01 
NIH/NIDDK 
09/01/2023 - 08/31/2025 
Dissecting the role of maternal nutrition on liver health: Implications for mother and baby. 

Harold Hamm Diabetes Center (MPIs: Short, Mitchell)
05/22/2023–03/15/2026 
Maternal obesity and diet: Impact on liver and metabolic health during pregnancy and postpartum. 
Total costs: $140,000 

Select Publications:

  1. Mitchell, CM*, Stinson EJ*, Chang DC, Krakoff J. A mixed meal tolerance test predicts onset of type 2 diabetes in Southwestern Indigenous Adults. Nutr & Diab. Accepted: February 23, 2024.  *Authors contributed equally and share first authorship
  2. Stinson EJ*, Mitchell CM*, Looker HC, Krakoff J, Chang DC. Higher glucose and insulin responses to a mixed meal are associated with increased risk of diabetic retinopathy in Indigenous Americans. J Endocrinol Invest. 2023 Sep 9;. doi: 10.1007/s40618-023-02187-0. [Epub ahead of print] PubMed PMID: 37684485. *Authors contributed equally and share first authorship
  3. Mitchell CM, Oxtoby LE, Shaw PA, Budge SM, Wooller MJ, Cabeza de Baca T, Krakoff J, Votruba S, O'Brien DM. Carbon Isotope Ratios of Plasma and RBC Fatty Acids Identify Meat Consumers in a 12-Week Inpatient Feeding Study of 32 Men. J Nutr. 2023 Jan 14;152(12):2847-2855. doi: 10.1093/jn/nxac213. PubMed PMID: 36095134; PubMed Central PMCID: PMC9839995.
  4. Wedekind LE, Mitchell CM, Andersen CC, Knowler WC, Hanson RL. Epidemiology of Type 2 Diabetes in Indigenous Communities in the United States. Curr Diab Rep. 2021 Nov 22;21(11):47. doi: 10.1007/s11892-021-01406-3. Review. PubMed PMID: 34807308; PubMed Central PMCID: PMC8665733.
  5. Mitchell CM, Davy BM, Ponder MA, McMillan RP, Hughes MD, Hulver MW, Neilson AP, Davy KP. Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial. Nutrients. 2021 Sep 17;13(9). doi: 10.3390/nu13093235. PubMed PMID: 34579112; PubMed Central PMCID: PMC8471706.
  6. Mitchell CM, Piaggi P, O'Brien DM, Krakoff J, Votruba SB. Metabolic Characterization of Meat, Fish, and Soda Intake in Males: Secondary Results from a Randomized Inpatient Pilot Study. Obesity (Silver Spring). 2021 Jun;29(6):995-1002. doi: 10.1002/oby.23167. Epub 2021 May 3. PubMed PMID: 33938613; PubMed Central PMCID: PMC9528993.
  7. Mitchell CM, Piaggi P, O'Brien DM, Krakoff J, Votruba SB. Metabolic Characterization of Meat, Fish, and Soda Intake in Males: Secondary Results from a Randomized Inpatient Pilot Study. Obesity (Silver Spring). 2021 Jun;29(6):995-1002. doi: 10.1002/oby.23167. Epub 2021 May 3. PubMed PMID: 33938613; PubMed Central PMCID: PMC9528993.
  8. Mitchell CM, Davy BM, Halliday TM, Hulver MW, Neilson AP, Ponder MA, Davy KP. The effect of prebiotic supplementation with inulin on cardiometabolic health: Rationale, design, and methods of a controlled feeding efficacy trial in adults at risk of type 2 diabetes. Contemp Clin Trials. 2015 Nov;45(Pt B):328-337. doi: 10.1016/j.cct.2015.10.012. Epub 2015 Oct 28. PubMed PMID: 26520413; PubMed Central PMCID: PMC4743874.