Active Studies

Active Studies

Tobacco

Tobacco Treatment Research Program

PI: Darla Kendzor

The Tobacco Treatment Research Program (TTRP) offers free tobacco cessation counseling and pharmacotherapy to the public and facilitates the recruitment, screening, and enrollment of participants into research studies.

Prevail II

PI: Darla Kendzor

This 2-armed NIH R01 (N=320) is a randomized clinical trial that will evaluate the long term impact of an adjunctive, low-cost contingency management (CM) intervention (relative to standard care) on smoking abstinence rates among socioeconomically disadvantaged individuals (Aim 1). The second aim of this study will seek to identify treatment mechanisms and contextual factors associated with cessation outcomes both traditional and ecological momentary assessment (EMA) approaches.

Combo

PIs: Darla Kendzor & Emily Hébert

This pilot study (N=100) is a 4-armed randomized controlled smoking cessation trail that will evaluate whether the combination of Varenicline and oral NRT (gum or lozenges) increases the likelihood of longer term smoking abstinence (Aim 1). The second aim of this study will determine the effect of medication reminders on pharmacotherapy adherence and cessation. The third aim will characterize and compare the course of withdrawal symptoms and side effects within measured in real time via ecological momentary assessment (EMA) and to determine their influence on the likelihood of cessation.

Phoenix

PI: Michael Businelle 

This pilot study (N=150) is a 3-armed randomized controlled smoking cessation induction trial that will determine the initial utility of a novel smartphone based intervention compared with an attention control group among smokers who are not ready to quit.

Smart-T3

PI: Michael Businelle

This NCI R01 randomized clinical trial (N=450) will compare the longer-term effects of the Smart-T smoking cessation app with the free and publicly available NCI QuitGuide smoking cessation app (Aim 1). The second aim of the study will determine if Smart-T messages that are tailored to address key smoking lapse risk variables in real-time (i.e., urge, stress, cigarette availability, cessation motivation) reduce participant ratings of these lapse risk variables compared with similar situations that do not receive this tailored content (QuitGuide group). For more information, visit the study's ResearchGate page here.

The Application of a Smartphone-Based Smoking Cessation Tool with American Indian Adults

PI: Michael Businelle and Ashley Cole

This NCI Diversity Supplement will support Dr. Ashley Cole’s development into an independent reseacher. This study involves qualatative examination of ways the Smart-T3 app can be culturally tailored for American Indian smokers seeking smoking cessation treatment. R01CA221819-01A1S1

Randomized Trial of Automated Video-Assisted Smoking Treatment for People Living with HIV

Site PI: Thanh Bui

The purpose of this randomized controlled trial is to evaluate a fully automated smartphone smoking-cessation intervention for HIV-positive smokers in Tampa (FL), Oklahoma City (OK), and Houston (TX).

Project Enhance

 PI: Amy Cohn

This NIH R01 is a clinical trial that will examine young adult appeal and reinforcement for menthol and non-menthol very low nicotine cigarettes using laboratory topography, ecological momentary assessment, and an experimental tobacco marketplace paradigm. For study updates, visit the Health Evaluation, Assessment, and Learning lab (HEAL lab) website for more information. (R01DA050990-01)

PRISM

PI: Amy Cohn

This NIH R01 is a clinical trial that will examine appeal and reinforcement for smoking menthol and non-menthol normal cigarettes using laboratory topography and ecological momentary assessment in young adults who recently started smoking. For study updates, visit the Health Evaluation, Assessment, and Learning lab (HEAL lab) website for more information. (R01DA046359-01)

Health Behaviors During Pregnancy

PI: Amy Cohn

This pilot project is funded by the OUHSC Department of Pediatrics through the University Hospital Authority Trust (UHAT). It is a longitudinal observational study that will examine health behaviors and trajectories of e-cigarette and other tobacco use during pregnancy. For study updates, visit the Health Evaluation, Assessment, and Learning lab (HEAL lab) website for more information.

Project Trinity (Health, Hope, and Healing): The Oklahoman African American Health Cohort Study

PI: Adam Alexander

HPRC CO-I(s): Kendzor; McQuoid

Project Trinity aims to provide data and insights that can be used by policymakers, public health professionals, and researchers in Oklahoma. This information can be used to inform public policy and research to promote health equity and to restore trust between African Americans, law enforcement and other public institutions. More broadly, the study will support grant applications that focus on reducing tobacco use, increasing physical activity, and addressing other modifiable health risk behaviors among African Americans.

Using Machine Learning to Develop Just-in-Time Adaptive Interventions for Smoking Cessation

PI: Emily Hébert

Feasibility of Using Biomarkers to Improve Smoking Cessation in American Indians with Diabetes

PI: Sydney Martinez, PhD

The primary objectives of this study are to (a) describe the glucose profiles and smoking behaviors among AI smokers with T2DM before and during a cessation attempt and (b) explore the usability, acceptability, and feasibility of integrating CGM and CO monitoring into routine T2DM care during smoking cessation. With this seed funding, the study team will leverage existing research and collaborations at Cherokee Nation and expand our team and methods to include the use of HPRC’s Mobile Health Shared Resource and HPRC Faculty Dr. Frank-Pearce for biostatistical expertise. This funding will provide the opportunity to pilot test our CGM and smoking cessation mHealth protocol and gather the preliminary data needed to submit an NIH R01 for a larger well-powered study.

Measuring Dependence Among Adult American Indian Smokeless Tobacco Users

PI: Nasir Mushtaq, PhD, MBBS, MPH

The primary objectives of this research are to (a) measure dependence among American Indian (AI) adults exclusive of smokeless tobacco (ST) users and (b) identify factors associated with ST dependence among AI adults. The long-term goal is to understand factors and processes resulting in continued ST use among AIs. This research is expected to identify different aspects of ST dependence among AIs and elucidate the role of social and cultural factors in ST dependence resulting in important evidence which will be used for the development of effective ST cessation interventions.

Identifying Factors Associated With Vaping Lapse During a Quit Attempt

PI(s): McQuoid, Hébert, Tackett

The overall objective of this application is to evaluate the needs of e-cigarette users undergoing a quit attempt to inform the development of an evidence-based, just-in-time, adaptive intervention for e-cigarette cessation.
 

Improving access to cigarette cessation treatment among African American smokers: Development and evaluation of an integrated mHealth application

PI(s): Obasi (Businelle & Zvolensky PIs on Study 1)

This study will refine and evaluate an initially developed and tested, novel, mobile intervention that targets sensitivity to bodily sensations among African American smokers and bridges the gap in access to care which has plagued this health disparities population.
 

Mobile Health Technology for Personalized Tobacco Cessation Support in Laos (Support Laos)

PI: Bui 

HPRC Co-I: Businelle 

This research project aims to adapt and evaluate the efficacy of our theoretically and empirically based mobile health (mHealth) technology to help people quit smoking cigarettes in Lao People’s Democratic Republic.
 

Pilot Study to Evaluate a Behavioral Activation Prenatal and Postpartum Intervention for Depressed Pregnant Smokers

PI: Blalock (MD Anderson Cancer Center)

HPRC Co-I: Kendzor

The aims of the project are to: 1) Conduct qualitative group interviews with depressed pregnant smokers and depressed smokers within the first 4 months of the postpartum period, to adapt and refine the delivery of an existing behavioral intervention via smartphone videoconferencing, 2) pilot test the delivery of the intervention, and 3) conduct a preliminary randomized trial.

 

Mindfulness-Based Smoking Cessation Mobile App Designed for Low-Income Smokers

PI: Spears (Georgia State University)

HPRC Co-I: Kendzor

The aims of the project are: 1) to develop iQuit Mindfully 2.0 using an existing mHealth app platform to deliver mindfulness-based smoking cessation treatment that is specifically designed for low-SES smokers, 2) refine iQuit Mindfully 2.0 based on usability testing with low-SES smokers, and 3) evaluate the feasibility of iQuit Mindfully 2.0 in a randomized controlled pilot trial. 
 

Incentives to Promote Smoking Cessation for Individuals with Diabetes

PI: Martinez (OUHSC College of Public Health)

HPRC Co-I: Kendzor

The primary aims of this project are to 1) evaluate the feasibility and preliminary effectiveness of contingency management as an adjunct to standard care (relative to standard care alone) on improving smoking abstinence rates among individuals with type 2 diabetes, and 2) identify diabetes-related contextual factors associated with study engagement and cessation outcomes among intervention participants. 
 

Automated Mobile Contingency Management for Smoking Cessation

PI: Kendzor

HPRC Co-I(s): Businelle; Frank-Pearce

The primary aim of this pilot randomized controlled trial is to evaluate the preliminary efficacy of an automated, mobile phone-based CM approach relative to standard care on smoking cessation 12 week after a quit attempt among socioeconomically disadvantaged adults. 
 

Partnering with a State Food Bank to Provide Tobacco Treatment to Underserved Smokers

PI(s): D. Vidrine; J. Vidrine

HPRC Co-I: Businelle

The overall goal of this project is to collaborate with a large food bank to evaluate the efficacy and economic impact of a theoretically-based, fully automated, interactive smartphone-based smoking cessation intervention.
 

A Comparison of the Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy versus Varenicline Alone for Smoking Cessation: A Pilot Study

PI: Kendzor

The aims of this study are to: 1) determine whether the combination of Varenicline and oral NRT (gum or lozenges based on participant preference) increases the likelihood of biochemically-verified smoking cessation relative to varenicline alone at 12 and 26 weeks following a scheduled quit attempt, and 2) characterize the effect of medication reminders on pharmacotherapy adherence. 
 

Piloting a Mobile Health Mixed Method Approach to Understand Rural Cancer Risk-related Substance Use Behaviors: Combining Smartphone Data Collection with Qualitative Mapping

Automated Mobile Contingency Management for Smoking Cessation Among Socioeconomically Disadvantaged Adults

(PI: Kendzor; Co-I: Businelle)      

 

The purpose of this study is to evaluate the efficacy and cost-effectiveness of an automated, smartphone-based approach to incentivizing smoking cessation.

HealthyCells: A Culturally-Tailored Smoking Cessation Smartphone Intervention for African Americans with Adjunctive Treatment for Sedentary Behavior

PI: Alexander, Businelle, Kendzor

This NIMHD career development award focuses on developing an innovative culturally tailored smartphone intervention that uses contingency management and sedentary behavior reduction to improve smoking cessation outcomes among African American smokers.

Mobile Health Technology to Monitor Risk for COVID-19 and Improve Mental Health during the Pandemic

MPIs: Businelle, Zvolensky; Co-I: Kendzor

Evaluate the efficacy of the Easing Anxiety Sensitivity for Everyone (EASE) app (N=800) which includes COVID-19 symptom monitoring and intervention and targets anxiety sensitivity, a transdiagnostic individual difference factor implicated in the etiology, maintenance, and progression of anxiety and depressive symptoms.

Homeless

Exchange (Survey Study and Sub-Study)

PI: Darla Kendzor

The survey study will assess characteristics and needs of up to 1000 adults who receive services at the Oklahoma City Homeless Alliance Day Shelter (Aim 1). The second aim of the survey study is to characterize tobacco and e-cigarette use patterns, tobacco history, past cessation attempts and assess interest in tobacco cessation and tobacco harm reduction intervention approaches. A 2-armed sub-study (N = 60) will characterize reductions in cigarette smoking following the provision of an e-cigarette device (JUUL) with supplies and the ability to earn financial incentives for switching over from combustible cigarettes to e-cigarettes exclusively.

Link2Care

PIs: Michael Businelle & Jennifer Reingle Gonzalez

This 3-armed NIH R01 is a randomized clinical trial that will use an innovative smartphone application to identify and address barriers that prevent recently incarcerated homeless adults from obtaining available case management, crisis management, substance abuse, and mental health services. For study updates, visit the study's ResearchGate page here.

ResearchGate 

Smart-T Alcohol

PIs: Michael Businelle & Scott Walters

This 2 phase NIH Funded R34 aims to develop and test a “just in time” adaptive intervention to reduce alcohol use in homeless men and women. Phase I utilizes smartphones and passive sensing technologies to monitor geolocation, psychosocial variables (e.g., stress, affect, urge to drink), and alcohol use (SCRAM). Phase II will use this information to provide tailored treatment messages that anticipate and intervene to prevent drinking and heavy drinking. For more information, visit the study's ResearchGate page here.

ResearchGate

Cancer

Persist

PI: Michael Businelle& Rachel Funk-Lawler

This pilot randomized controlled trial (N=60) will assess the initial feasibility of a phone-delivered intervention for anxiety and depressive symptoms among cancer patients that are receiving active radiation treatments.

Symptom Tracker

PI: Michael Businelle and Katherine Moxley

The NCI funded Symptom Tracker study will use a novel smartphone app to follow 500 patients who are receiving chemotherapy daily for 24 weeks. When COVID-19 symptoms are detected, the app assesses COVID-19 risk, provides information (e.g., locations of testing sites), and connects the patient health care professionals. When/if a patient tests positive for COVID-19, the app assess symptom severity each day and provides advice/connections when severe symptoms are detected.

Linking Health Risk Factors, Systemic DNA Damage, and Cervical Cancer Risk

PI: Lurdes Queimado 

The primary objectives of this study are to (a) determine whether the level of DNA damage in peripheral blood cells (PBC) correlates with the grade of cervical dysplasia and cancer and (b) assess whether the risk factors for development of cervical dysplasia and cancer correlate with the systemic levels of DNA damage. The data will integrate DNA damage and modifiable health risk factors to deliver novel strategies that will effectively reduce cervical cancer incidence and mortality in Oklahoma

Piloting a Mobile Health mixed method to understand rural cancer risk-related substance use behaviors: combining smartphone data collection with qualitative mapping

Stephenson Cancer Center – Cancer Center Support Grant

PI: Mannel

Co-I(s): Businelle, Kendzor

Businelle directs the mHealth Shared Resource; Kendzor directs the Cancer Prevention and Control Program

 

HPV Vaccine

Using Partner referral to Increase Human Papillomavirus Vaccine Uptake (Uptake 1)

PI: Bui

The purpose of this mixed-methods pilot study is to determine the feasibility of an innovative, evidence-based approach—partner referral—to increase HPV vaccine uptake in people living with HIV in Oklahoma City, OK,

Promoting Human Papillomavirus Vaccine Uptake in High-Risk Adults (Uptake 2)

PI: Bui

This pilot study aims to determine the preliminary efficacy of an innovative, theory-based approach that combines partner referral and peer-driven intervention to increase human papillomavirus vaccine uptake in eligible high-risk adults in Oklahoma City, OK.

Relational Agents in HPV Vaccine Education

(PI: Gogoi; Co-I: Bui)

The purpose of this project is to explore effective strategies to educate survivors of an HPV related disease (e.g., cervical cancer) about the importance of HPV vaccination and to engage them in promoting HPV vaccination. Study sites include the NCI-designated Stephenson Cancer Center at The University of Oklahoma Health Sciences Center and the Karmanos Cancer Institute (KCI) at Wayne State University.

Marijuana

IMMPACT-Investigating Medical Marijuana Public Health Impact in Oklahoma

 PIs: Amy Cohn and Darla Kendzor

This cross-section study will examine health behaviors and attitudes about marijuana legalization in three separate cohorts of 2,000 individuals living in Oklahoma. Cohorts will be assessed 6-months apart. For study updates, visit the Health Evaluation, Assessment, and Learning lab (HEAL lab) website for more information.

Developing a statewide survey to evaluate the impact of medical cannabis use on youth and adult substance use and health outcomes

PI: Cohn

MPI: Kendzor

This multi-wave panel survey assesses the impact of medical cannabis legalization on substance use behavior, perceptions, and health status among (n = 2,000) youth and adults living in Oklahoma. 
 

Characterizing Cannabis Use among Adults Undergoing Cancer Treatment

PI(s): Kendzor/Cohn

The primary objectives of this longitudinal project are to 1) characterize the prevalence, purpose, frequency, and modality of cannabis use; as well as the perceived physical and psychological effects of cannabis use (negative and positive) among adults undergoing cancer treatment (over 6 months), 2) compare the frequency and severity of physical and psychological symptoms between those who use cannabis and those who do not, 3) compare opiate and other medication use among those who use cannabis and those who do not, and 4) assess providers’ beliefs and practices related to cannabis use in their patients.
 

PHYSICAL ACTIVITY

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